Whole Genome Sequencing (WGS) for Therapeutic Cell Characterization

Comprehensive Genome Integrity Assessment – Dual short- and long-read WGS to detect SNVs, structural variants, copy number changes, and complex integrations impacting therapeutic cell safety.

Regulatory-Ready Tumorigenicity Risk Evaluation – CGMP/GLP-aligned sequencing workflows generating submission-quality data to support IND advancement and clinical development.

Whole Genome Sequencing (WGS) Services

Genome-Wide Variant Detection – High-coverage short-read sequencing (>50x) to detect SNVs, indels, and small copy number variants, with annotation against clinically relevant databases to assess pathogenicity and cancer relevance.
Structural Variant & Chromosomal Analysis – Long-read sequencing (>15x) to identify large insertions/deletions, inversions, translocations, complex rearrangements, copy number alterations, and aneuploidy.
Unbiased Integration Site Analysis – Short- and long-read workflows to detect vector integration events, characterize intact vs. rearranged insertions, and identify off-target integrations and concatemers.
Comparative Genomic Stability Studies – Bank-to-bank or passage-to-passage comparisons to evaluate clonal integrity, genomic drift, and long-term stability.
Tumorigenicity Risk Assessment Support – Focused evaluation of tumor suppressor, oncogene, DNA repair, and cell cycle–related variants to inform safety assessment.

Our Expertise

Dual-Technology WGS Strategy – Integrated short-read sensitivity and long-read structural resolution for comprehensive genomic profiling.
Optimized Study Design – Strategic planning aligned with therapeutic cell platform and development stage.
Advanced Library Preparation & QC – Robust workflows for high-quality genomic DNA processing and coverage consistency.
Integrated Bioinformatics Analysis – Variant calling, structural analysis, annotation, and genome architecture reporting under controlled pipelines.
Therapeutic Cell Experience – Extensive support for iPSC-derived products, CAR-T/TCR-T therapies, gene-edited cells, and production cell lines.

Partnering for Regulatory Success

Avance Biosciences delivers regulatory-ready whole genome sequencing data generated under CGMP/GLP-aligned workflows. Our validated NGS platforms and disciplined analytical processes provide reproducible results and complete traceability to support IND, BLA, and global regulatory submissions with confidence.

Our Customers Say…

Your team met the timelines we needed and did exceptional technical work. I will definitely make my management aware that Avance is a very capable partner for our bioanalytical needs.

Bioanalytical Senior Project Manager, California

Avance Biosciences™ (AB) has delivered the Sequencing data in a record time. Very impressive! We have benefited from AB’s hard work and are very grateful for that. AB team should feel proud of themselves. We thank AB team for their support and contributions, much appreciated.

Head of Quality Control, Microbial Manufacturing Service, California

My experience with Avance has been nothing but positive… I will keep sending work your way as I appreciate the attention your team provides and Avance’s creative technical team. See you soon.

Director Individualized Medicines, California

Avance has been the ideal partner in helping Mission Bio and our client,… be the first in the world to GMP qualify our single cell % transduction assay for a lentiviral gene therapy product. Excellent execution on the part of the Avance team. We look forward to more collaborations in the future.

Senior Director, Cell & Gene Therapy Business, California

From the preliminary conclusion of this work, we are already pleased to thank you for your customer-oriented approach and proactive communication in the course of this study. We are happy to see the profound difference in business mindset between your organization and our previous vendor…

Project Manager, Belgium

Thank you so much for successfully completing this important project for us on time. We are very satisfied with the final report and thank you for taking the extra effort to customize the report format. We will definitely use your lab for future projects.

Program Manager, California

It has been a pleasure working with you and your team. The project was carried out to the highest standard and delivered in a timely manner. I will definitely recommend Avance Biosciences™’ services to colleagues and friends.

Senior Scientist, Singapore