Avance Biosciences™ is offering NGS services to help our clients to characterize bacterial cell lines and viral genomes, as well as other small genomes including plasmids.  Sequencing libraries will be prepared using high fidelity amplification enzymes and use PCR-free protocols if possible to reduce potential bias introduced by PCR.

Although Sanger sequencing is the “Gold-Standard” for analyze genomic sequences for FDA submission purposes, its low detection limit makes it ill fit to evaluate rare mutations/alleles when their populations are below 15%.  NGS method is the method of choice for characterizing bacterial genomes, viral genomes, and some of the gene constructs that may contain low frequency of indels and mutations.

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Services

GLP/GMP Compliant
Genomics & Biological Services

  • Experienced scientists functioning as project managers or study directors

  • Independent quality unit assuring regulatory compliance

  • Methods validated per ICH GLP/GMP guidelines – also research grade testing available

  • Rigorous sample tracking and handling procedures to prevent mistakes and cross-contamination

  • Controlled laboratory environment to prevent cross-contamination

When you partner with Avance Biosciences™, you gain a CRO partner that is creative, collaborative and dedicated to sound science with a focus on the regulatory requirements our partners require. Contact our technical staff to discuss how we can support you in your project!

Partner

Dedication to Quality

Dedication To Quality

The Avance Biosciences™ team is committed to strict adherence to CGMP and GLP regulations enacted by the US, European, Japanese, and other international regulatory agencies.

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Extensive Experience

Open Communication

Our team has extensive knowledge and experience working with scientists, QA/QC professionals, and project managers from over 100 pharmaceutical and biotechnology companies and organizations throughout the world.

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Open Communication

Open Communication

Transparency and integrity are two of our core values. Our well-trained, friendly, and professional study directors and project managers strive to complete your projects on-time with open communication channels and to your specifications.

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Cutting Edge Science

Open Communication

Avance Biosciences™’ CGMP/GLP compliant genomic and microbial assays make use of the advanced technologies including real-time PCR, ddPCR, Sanger sequencing, next-gen sequencing, Southern blot, and more.

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