Avance Biosciences

CGMP/GLP-Compliant Next Generation DNA Sequencing Services

Comprehensive NGS for Biopharma Development – Short-read, long-read, and single-cell sequencing to support gene therapy, biologics, and advanced therapeutics.

Regulatory-Compliant Genomic Analysis – CGMP/GLP-aligned workflows delivering high-quality sequencing data for IND-enabling and clinical programs.

Avance Biosciences’ Next-Generation Sequencing (NGS) Center of Excellence provides comprehensive DNA and RNA sequencing services to support biologics, gene therapy, and cell therapy development. Our laboratory integrates short-read sequencing, long-read sequencing, and single-cell sequencing technologies to deliver deep genomic insights for preclinical studies, clinical studies, and CMC support.

Sequencing Platforms

Short-Read Sequencing

  • Illumina MiSeq,
    NextSeq 550

  • Element AVITI

Long-Read Sequencing

  • Nanopore MinION,
    P2 Solo

  • PacBio Vega

Single-Cell Sequencing

  • 10X Genomics Chromium X

  • Mission Bio Tapestri

Assays Supported

Safety / Contaminants

  • Adventitious Agents

  • Metagenomics: Microbes & Contaminants

Identity & Structure

  • Amplicon Sequencing

  • Plasmid & Vector Identity

Genome-wide Characterization

  • Whole Genome Sequencing

  • Integration Site Analysis

  • Variant Calling

  • Epigenetics: DNA Methylation Profiling

Functional Editing

  • CRISPR Screening

  • On/Off Target Analysis

  • Gene Editing PK Study

Our Expertise

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  • Optimized Experimental Design – Strategic study planning to maximize data quality, resolution, and biological insight.

  • Advanced Sample & Library Preparation – Expert handling of challenging samples for multiomic workflows.

  • Regulatory Compliant Bioinformatics Analysis – Robust infrastructure and secure data handling supported by in-house expertise, on-premises NGS analysis servers, and 21 CFR Part 11 compliance with full audit trails.

Partnering for Regulatory Success

As your partner in drug development, Avance Biosciences delivers regulatory-ready data backed by validated NGS platforms and expert bioinformatics. Our services are fully integrated with GLP and GMP standards, ensuring precise mapping, reproducible results, and complete data traceability to support your IND, BLA, or other global regulatory submissions with confidence.

Our Customers Say…

Your team met the timelines we needed and did exceptional technical work. I will definitely make my management aware that Avance is a very capable partner for our bioanalytical needs.

Bioanalytical Senior Project Manager, California

Avance Biosciences™ (AB) has delivered the Sequencing data in a record time. Very impressive! We have benefited from AB’s hard work and are very grateful for that. AB team should feel proud of themselves. We thank AB team for their support and contributions, much appreciated.

Head of Quality Control, Microbial Manufacturing Service, California

My experience with Avance has been nothing but positive… I will keep sending work your way as I appreciate the attention your team provides and Avance’s creative technical team. See you soon.

Director Individualized Medicines, California

Avance has been the ideal partner in helping Mission Bio and our client,… be the first in the world to GMP qualify our single cell % transduction assay for a lentiviral gene therapy product. Excellent execution on the part of the Avance team. We look forward to more collaborations in the future.

Senior Director, Cell & Gene Therapy Business, California

From the preliminary conclusion of this work, we are already pleased to thank you for your customer-oriented approach and proactive communication in the course of this study. We are happy to see the profound difference in business mindset between your organization and our previous vendor…

Project Manager, Belgium

Thank you so much for successfully completing this important project for us on time. We are very satisfied with the final report and thank you for taking the extra effort to customize the report format. We will definitely use your lab for future projects.

Program Manager, California

It has been a pleasure working with you and your team. The project was carried out to the highest standard and delivered in a timely manner. I will definitely recommend Avance Biosciences™’ services to colleagues and friends.

Senior Scientist, Singapore