CRISPR, a potent gene editing tool, empowers scientists to enact precise modifications in ex vivo gene editing for cell therapy and in vivo gene therapy, unlocking unparalleled possibilities for addressing genetic disorders.  As this revolutionary technology continues to progress, so does the need for rigorous characterization of the edited genes in compliance with regulatory requirements.

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The Avance Biosciences™ team is your trusted partner in navigating the complex analytical landscape of gene editing. Boasting more than 20 years of expertise in pioneering biological assay development and validation, we deliver cutting-edge solutions for evaluating the effectiveness of on-target editing and monitoring off-target editing events in gene-edited T-cells, stem cells, iPSC, sgRNA/mRNA in LIPID, and for both preclinical and clinical research studies.

Expert On/Off Target Screening & Analysis

To meet evolving regulatory requirements, standards and to mitigate risk, researchers utilizing tools such as CRISPR and other gene editing platforms must proactively identify and address off target effects, as well as any unintended modifications at a non-target site such as translocation possibilities.

Fortunately, modern genomic assay platforms — including NGS and ddPCR— provide effective, reliable means to identify off target effects and events, including point mutations, deletions, insertions, inversions, and unexpected translocations.

As an experienced leader and partner in the field of CRISPR gene editing, Avance Biosciences™ provides a comprehensive range of off target services. Using robust GMP/GLP processes — as well as state-of-the-art NGS and ddPCR platforms that optimize scalability, speed, and cost — we help life science researchers take a proactive, strategic approach to off site screening, analysis, and intervention.

Identification and Quantification of Off-Target Effects

To meet evolving regulatory standards and ensure the safety and efficacy of gene editing-based therapies, researchers must take proactive measures to detect and mitigate off-target effects. Avance Biosciences™ offers a comprehensive range of services to support your development efforts:

Improve Off Target Analysis with Avance As Your Partner

Why Choose Avance Biosciences™?

  • Experience: With over 20 years in the industry, our team brings unparalleled expertise to your gene editing projects.
  • Regulatory Compliance: We operate in compliance with GLP and GMP guidelines, ensuring your data stands up to regulatory scrutiny.
  • Cutting-Edge Technology: Our use of NGS, ddPCR, and advanced bioinformatics allows for precise and reliable analysis.
  • Collaborative Partnership: We work closely with you to develop scientific and operational roadmaps aligned with your research, clinical, and commercial objectives.

Contact Us

Unlock the full potential of your gene editing programs with Avance Biosciences. Contact us today to learn more about our on/off-target gene editing services and discover how we can help you navigate the evolving CRISPR gene editing landscape.

Have questions?

Reach out to the off target experts at Avance Biosciences™ today.


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Thank you so much for successfully completing this important project for us on time. We are very satisfied with the final report and thank you for taking the extra effort to customize the report format. We will definitely use your lab for future projects.

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It has been a pleasure working with you and your team. The project was carried out to the highest standard and delivered in a timely manner. I will definitely recommend Avance Biosciences™’ services to colleagues and friends.

Senior Scientist, Singapore

When you partner with Avance Biosciences™, you gain a CRO partner that is creative, collaborative and dedicated to sound science with a focus on the regulatory requirements our partners require. Contact our technical staff to discuss how we can support you in your project!


Dedication to Quality

Dedication To Quality

The Avance Biosciences™ team is committed to strict adherence to CGMP and GLP regulations enacted by the US, European, Japanese, and other international regulatory agencies.


Extensive Experience

Open Communication

Our team has extensive knowledge and experience working with scientists, QA/QC professionals, and project managers from over 100 pharmaceutical and biotechnology companies and organizations throughout the world.


Open Communication

Open Communication

Transparency and integrity are two of our core values. Our well-trained, friendly, and professional study directors and project managers strive to complete your projects on-time with open communication channels and to your specifications.


Cutting Edge Science

Open Communication

Avance Biosciences™’ CGMP/GLP compliant genomic and microbial assays make use of the advanced technologies including real-time PCR, ddPCR, Sanger sequencing, next-gen sequencing, Southern blot, and more.