Quantitative analysis of gene editing is now an essential step in getting regulatory approval of gene editing-based therapies. But designing and validating assays for on/off-target editing analysis and building an internal team to perform them can be costly and inefficient.
Avance Biosciences™ offers sensitive and high-throughput amplicon sequencing to help your team accurately quantify on-target editing efficiency and off-target editing events at predicted loci, including chromosome translocation events. Our experienced team operates in compliance with both GLP and GMP guidelines, empowering you with data that holds up against regulatory scrutiny. Our flexibility and extreme attention to detail have helped pre-clinical and clinical-stage biopharmaceutical companies usher in the next generation of gene and cell therapies.
Expert On/Off Target Screening & Analysis
To meet evolving regulatory requirements, standards and to mitigate risk, researchers utilizing tools such as CRISPR and other gene editing platforms must proactively identify and address off target effects, as well as any unintended modifications at a non-target site such as translocation possibilities.
Fortunately, modern genomic assay platforms — including NGS and ddPCR— provide effective, reliable means to identify off target effects and events, including point mutations, deletions, insertions, inversions, and unexpected translocations.
As an experienced leader and partner in the field of CRISPR gene editing, Avance Biosciences™ provides a comprehensive range of off target services. Using robust GMP/GLP processes — as well as state-of-the-art NGS and ddPCR platforms that optimize scalability, speed, and cost — we help life science researchers take a proactive, strategic approach to off site screening, analysis, and intervention.
Fortunately, modern genomic assay platforms — including NGS and ddPCR— provide effective, reliable means to identify off target effects and events, including point mutations, deletions, insertions, inversions, and unexpected translocations.
As an experienced leader and partner in the field of CRISPR gene editing, Avance Biosciences™ provides a comprehensive range of off target services. Using robust GMP/GLP processes — as well as state-of-the-art NGS and ddPCR platforms that optimize scalability, speed, and cost — we help life science researchers take a proactive, strategic approach to off site screening, analysis, and intervention.
On- and Off-Target Gene Editing Analysis Services
As a genomics company, we offer a variety of services that can provide a holistic view of your gene editing profile.
On-Target Gene Editing Quantification
Off-Target Gene Editing Analysis
On-Target Gene Editing Analysis
with ddPCR
Improve Off Target Analysis with Avance As Your Partner
Avance Biosciences™ has more than two decades of experience providing advanced genomics services. As a true collaborative partner, we help you create a scientific and operational roadmap that helps you meet research, clinical, and commercial objectives. We’re ready and able to help you characterize your product’s off target site impact in detail, as well as navigate the evolving CRISPR gene editing standards laid out by the FDA and other regulatory bodies worldwide.
Our Customers Say…
From the preliminary conclusion of this work, we are already pleased to thank you for your customer-oriented approach and proactive communication in the course of this study. We are happy to see the profound difference in business mindset between your organization and our previous vendor…
Project Manager, Belgium
Thank you so much for successfully completing this important project for us on time. We are very satisfied with the final report and thank you for taking the extra effort to customize the report format. We will definitely use your lab for future projects.
Program Manager, California
It has been a pleasure working with you and your team. The project was carried out to the highest standard and delivered in a timely manner. I will definitely recommend Avance Biosciences™’ services to colleagues and friends.
Senior Scientist, Singapore
When you partner with Avance Biosciences™, you gain a CRO partner that is creative, collaborative and dedicated to sound science with a focus on the regulatory requirements our partners require. Contact our technical staff to discuss how we can support you in your project!
