We are pleased to announce that Avance Biosciences Inc. is expanding its operations to a new facility located at 5500 Northwest Central Drive, Houston, Texas 77092.

As part of this transition, we have successfully completed a partial commissioning of the new site under Tier One of our implementation plan in accordance with the overall governing change control (CC-423} and its supporting change controls.

Effective July 21, 2025, Avance will provide GMP services under our Biologics Quality Control previously performed at Avance Biosciences site located at 9770 West Little York. The services provided during this initial phase will support the following platforms: Microbiology Sanger sequencing, and selected services.

Beginning immediately, sample materials should be shipped directly to 5500 Northwest Central Drive, Houston, Texas 77092 (USA) during business hours instead of Avance West Little York address. Any samples currently in transit to Avance West Little York site will be received and appropriately transferred to the new facility in accordance with the change control. This change does not affect the shipment and receiving of samples at Avance Empire Central site.

For any questions or assistance, please contact your Project Manager or Avance Sales Representative.

We appreciate your continued partnership and look forward to supporting your needs from our new location.

Respectfully,

The Avance Quality team