science

Cutting Edge Science

Avance Biosciences™’ cGMP/GLP compliant genomic assays make use of advanced technologies including real-time PCR, digital PCR, Sanger sequencing, next generation sequencing, and more.

qPCR

Avance Biosciences™ offers Real-Time PCR services with ABI 7900 HT, QuantStudio 7 Pro, and QuantStudio 12K Flex systems. Assays include Absolute & Relative Quantitation, Allelic Discrimination, and Plus/Minus, vital for genomics, drug R&D, and biologics testing.

ddPCR

Digital PCR provides precise nucleic acid quantification, ultrasensitive detection of low-abundance targets, and high precision for allelic variants and low-level pathogens. Avance Biosciences™ offers digital PCR services using Bio-Rad’s state-of-the-art QX200 digital droplet PCR system to support clients around the world.

CRISPRSanger
Sequencing

Avance Biosystems™ offers Sanger sequencing using ABI 3730 XL DNA Analyzer, a gold standard for clinical trials and assay validation. Services include DNA extraction, high-throughput sequencing, primer design, and comprehensive data analysis.

CAR T-Cell TherapyNext-Gen
Sequencing

Avance Biosciences™ offers cutting-edge NGS services using Illumina MiSeq, NextSeq 550, Oxford Nanopore MinION, and PromethION 2 Solo platforms. From short-read for targeted panels to long-read for genome analysis, we ensure accurate results to advance your research.

Single-cellSingle-Cell
Sequencing

Avance Biosciences™’ single-cell services for cell and gene therapies leverage the cutting-edge Mission Bio Tapestri® Platform to provide unparalleled insights into single-cell genomics. Explore cellular diversity and accelerate groundbreaking discoveries with us.

CAR T-Cell TherapyCell Biology

Avance Biosciences™ leverages cutting-edge technologies and cellular analysis platforms including the Chemometec NucleoCounter NC-200, STEMCELL TECHNOLOGIES STEMvision, and Beckman Coulter CytoFLEX to provide the most innovative solutions to our clients.

CAR T-Cell Therapy

Protein Analysis and
other Immunoassays

Avance Biosciences™ is now offering Western blot, ELISA (Enzyme-Linked Immunosorbent Assay) and other immunoassay services for protein analysis. Platforms include the Protein Simple – Jess System, the MesoScale Discovery MESO QuickPlex SQ 120MM and the BioTek Cytation 5 Cell Imaging Multi-Mode Reader.

Quality ControlDNA/RNA/Proteins
Quality Control

Avance Biosciences™ leverages the advanced capabilities of the NanoDrop 1000 Spectrophotometer, NanoDrop One Spectrophotometer, and Agilent 2100 Bioanalyzer to provide comprehensive solutions for DNA, RNA, and protein quality control with accuracy, efficiency, and reliability.

CAR T-Cell TherapyNucleic Acids
Processing/ Purification

Avance Biosciences™ capabilities for nucleic acid processing and purification include the ThermoFisher Scientific KingFisher Flex Purification System designed for nucleic acid purification and the Covaris ME220 Focused-ultrasonicator designed for precise and efficient shearing of nucleic acids.

Single-cellBiomolecular
Imaging

Avance Biosciences™ leverages the advanced platforms: GE Typhoon FLA 7000 and Bio-Rad Gel Doc XR+ System for biomolecular imaging, enabling the visualization and analysis of proteins, nucleic acids, and other biomolecules for various applications, including drug discovery, target validation, and quality control.

AutomationAutomation

Avance Biosciences™ state-of-the-art automation platforms, including the QIAGEN QIAgility, Tecan Freedom EVO, Eppendorf epMotion 5073t, and Agilent BioTek 405 TS Washer, streamline assay development, validation, and sample testing processes, ensuring efficiency, accuracy, and compliance with CGMP and GLP standards.

Capillary ElectrophoresisCapillary Electrophoresis

Avance Biosciences™ offers CGMP and GLP-compliant capillary electrophoresis services for biopharmaceutical development. Our SCIEX PA800 Plus system enables high-throughput analysis and precise separation for our assay development, validation, and sample testing services.

When you partner with Avance Biosciences™, you gain a CRO partner that is creative, collaborative and dedicated to sound science with a focus on the regulatory requirements our partners require. Contact our technical staff to discuss how we can support you in your project!

Partner

Dedication to Quality

Dedication To Quality

The Avance Biosciences™ team is committed to strict adherence to CGMP and GLP regulations enacted by the US, European, Japanese, and other international regulatory agencies.

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Extensive Experience

Open Communication

Our team has extensive knowledge and experience working with scientists, QA/QC professionals, and project managers from over 100 pharmaceutical and biotechnology companies and organizations throughout the world.

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Open Communication

Open Communication

Transparency and integrity are two of our core values. Our well-trained, friendly, and professional study directors and project managers strive to complete your projects on-time with open communication channels and to your specifications.

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Cutting Edge Science

Open Communication

Avance Biosciences™’ CGMP/GLP compliant genomic and microbial assays make use of the advanced technologies including real-time PCR, ddPCR, Sanger sequencing, next-gen sequencing, Southern blot, and more.

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