10X Chromium X Single Cell Sequencing Services
As part of our investment in advanced sequencing, Avance Biosciences has added the 10x Genomics Chromium X platform to our Advanced Sequencing Center . This technology enables high-resolution single-cell gene expression studies , supporting applications such as immuno-oncology, stem cell research, and cell and gene therapy. Integrated with our CGMP/GLP-compliant NGS workflows, it enhances our ability to characterize tissue and cell heterogeneity, identify rare cell types, and dissect molecular mechanisms cell by cell for complex biologics development.
Our Expertise
Our experienced scientists are highly skilled in sample preparation, library construction, and data analysis for single-cell RNA-seq, ATAC-seq, and multi-omic assays. We understand the unique challenges of single-cell workflows and work closely with our clients to optimize experimental design, maximize data quality, and deliver actionable insights. Our commitment to technical excellence and personalized support makes us a trusted partner for single-cell research and development.
Single Cell Sequencing Services
Primary Capability
Major Applications
Single Cell RNA-seq (3’ and 5’)
- Profile gene expression at single-cell resolution
- Identify cell types, states, and drug response
- Track transgene expression and engineered cell fate (e.g., CAR-T)
- Support MoA studies, biomarker discovery, and potency assessment
Single Cell ATAC-seq
- Map chromatin accessibility and regulatory element activity
- Uncover epigenetic changes linked to therapy, differentiation, or cell engineering
- Study transcription factor networks and regulatory programs
Multiomic Capability
Single Cell V(D)J Sequencing with 5’ Gene Expression
- Characterize TCR/BCR repertoires and clonal expansion
- Monitor engineered immune cell persistence and diversity (e.g., CAR-T, TCR-T)
- Assess host immune response, immunogenicity, and minimal residual disease
Multiome (RNA + ATAC)
- Integrate transcriptomic and epigenomic information from the same cell
- Elucidate gene regulatory mechanisms driving cell identity and therapeutic function
- Optimize vector design, transgene durability, and cell therapy performance
Spatial Transcriptomics (Visium) Cell Surface Protein with 3’ or 5’ Gene Expression
- Identify surface protein markers
- Categorize cell types
- Explore cell signaling and interactions
CRISPR Screening with 5’ Gene Expression
- Perform pooled gene perturbation with single-cell resolution
- Identify gene targets, resistance pathways, or synthetic lethal interactions
- Validate genome editing strategies and assess safety/function of edits