Cytokine Analysis Services
Assessing a drug’s impact on immune function is critical for safety evaluation. Cytokine release assays are a primary method to assess drug‑induced immune activation risk. These assays provide insights into how drugs affect immune responses, guiding trial design and enabling early detection of immune‑related events.
Cytokine Analysis Services
Assessing a drug’s impact on immune function is critical for safety evaluation. Cytokine release assays are a primary method to assess drug‑induced immune activation risk. These assays provide insights into how drugs affect immune responses, guiding trial design and enabling early detection of immune‑related events.
Our Expertise
With years of specialized experience, we excel in cytokine analysis to bolster our clients’ drug development endeavors. Utilizing cutting-edge platforms such as Cytation 5 (ELISA), MESO QuickPlex SQ 120 MM (MSD) and CytoFLEX (Flow Cytometry), we provide robust and precise cytokine profiling services. Our expertise ensures meticulous attention to detail, helping to understand the immune responses crucial for advancing therapeutic strategies and meeting regulatory standards effectively.
Cytokine Analysis Services
Technique
Principle
Advantages
ELISA (Enzyme-linked Immunosorbent Assay)
- Cytokine-specific antibodies are used for detection
- Amount of cytokine present is quantified via a colorimetric or fluorescent readout
- High sensitivity, specificity, and quantification range
- Well-established and widely used method
MSD (Meso Scale Discovery) Assay
- Electrochemiluminescence-based immunoassay
- Multiplex detection on microplates with capture antibodies spotted in spatially distinct regions (up to ~10 analytes per well).
- Enhanced sensitivity and dynamic range
- Multiplexing capability
- Pre-established cytokine panels
- Low sample volume requirement
Flow Cytometry
- Individual beads have unique fluorescent profiles
- Capture antibodies specific for different cytokines are coupled to different beads
- Enhanced sensitivity and dynamic range
- Multiplexing capability
- Low sample volume requirement