The Master Seed Bank or Master Virus Seed Stock (MVSS) should be extensively characterized to insure the resulting viral passages including the Working Virus Bank or Working Virus Seed Stock (WVSS) remain the same genotype and phenotype as the initial MVSS. This stability testing (sequencing and genetic stability) should be confirmed at viral passages beyond the manufacturing end point. Additional tests that are required for viral stocks include: identity, safety, purity, potency, fungal and bacterial sterility, mycoplasmas, and adventitious viral testing.
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