Next Generation Sequencing (NGS) has the potential to unlock causative factors from our genetic material. NGS also represents a technological advancement using array-based sequencing that will improve many aspects of scientific research and advance the field of personalized medicine.
Avance Biosciences™ offers several Next Generation Sequencing (NGS) services with Illumina’s MiSeq and HiSeq 2500 V4 platforms. Our NGS services are uniquely designed to support drug development and manufacturing. We help our biopharm and biotech partners to develop, validate, and perform NGS assays, in compliance with GLP or cGMP regulations if needed.
Avance Biosciences™ offers custom amplicon sequencing assay development and validation services to support our clients’ preclinical safety studies and clinical trial pharmacokinetics studies (GLP), as well as rare mutation detection in gene constructs utilized in drug manufacturing. State-of-the-art Illumina MiSeq platform is used.
Avance Biosciences™ is offering NGS services to help our clients to characterize bacterial cell lines and viral genomes, as well as other small genomes including plasmids. Sequencing libraries will be prepared using high fidelity amplification enzymes and use PCR-free protocols if possible to reduce potential bias introduced by PCR.
Next generation sequencing (NGS) is quickly gaining regulatory agencies’ acceptance as a sensitive and un-biased detection method for adventitious agents. Avance Biosciences™ is positioned to be a strategic partner with our pharmaceutical clients in establishing this powerful tool for testing viral contaminants in cell substrates and biological products.
Avance Biosciences™ offers mRNA-Seq service using Illumina next generation sequencing platform to identify all mRNA transcripts expressed in a biological sample and precisely measure the relative quantities of each transcript including each isoform having different splicing patterns.
Traditionally, Southern blot analysis is the method of choice to satisfy FDA’s requirements of charactering cell line genetic stability. Avance Biosciences™ is now offering two NGS approaches to analyze the transgene insertion sites.
Avance Biosciences™ offers Illumina’s TruSeq Amplicon – Cancer Panel (TSACP) to support cancer research. The TSACP is a highly multiplexed targeted resequencing assay for detecting somatic mutations, such as BRAF, KRAS, and EGFR.
We are dedicated to timely, high-quality service from the start of your project to the finish. Send us a note or give us a call to find out what Avance can do for you.
Avance Biosciences™ (AB) has delivered the Sequencing data in a record time. Very impressive! We have benefited from AB’s hard work and are very grateful for that. AB team should feel proud of themselves. We thank AB team for their support and contributions, much appreciated.
Head of Quality Control, Microbial Manufacturing Service, California
Your team met the timelines we needed and did exceptional technical work. I will definitely make my management aware that Avance is a very capable partner for our bioanalytical needs.
Bioanalytical Senior Project Manager, California
My experience with Avance has been nothing but positive… I will keep sending work your way as I appreciate the attention your team provides and Avance’s creative technical team. See you soon.
Director Individualized Medicines, California
Avance has been the ideal partner in helping Mission Bio and our client,… be the first in the world to GMP qualify our single cell % transduction assay for a lentiviral gene therapy product. Excellent execution on the part of the Avance team. We look forward to more collaborations in the future.
Senior Director, Cell & Gene Therapy Business, California
From the preliminary conclusion of this work, we are already pleased to thank you for your customer-oriented approach and proactive communication in the course of this study. We are happy to see the profound difference in business mindset between your organization and our previous vendor…
Project Manager, Belgium
Thank you so much for successfully completing this important project for us on time. We are very satisfied with the final report and thank you for taking the extra effort to customize the report format. We will definitely use your lab for future projects.
Program Manager, California
It has been a pleasure working with you and your team. The project was carried out to the highest standard and delivered in a timely manner. I will definitely recommend Avance Biosciences™’ services to colleagues and friends.
Senior Scientist, Singapore
When you partner with Avance Biosciences™, you gain a CRO partner that is creative, collaborative and dedicated to sound science with a focus on the regulatory requirements our partners require. Contact our technical staff to discuss how we can support you in your project!
Dedication to Quality
The Avance Biosciences™ team is committed to strict adherence to CGMP and GLP regulations enacted by the US, European, Japanese, and other international regulatory agencies.
Our team has extensive knowledge and experience working with scientists, QA/QC professionals, and project managers from over 100 pharmaceutical and biotechnology companies and organizations throughout the world.
Transparency and integrity are two of our core values. Our well-trained, friendly, and professional study directors and project managers strive to complete your projects on-time with open communication channels and to your specifications.
Avance Biosciences™’ CGMP/GLP compliant genomic and microbial assays make use of the advanced technologies including real-time PCR, ddPCR, Sanger sequencing, next-gen sequencing, Southern blot, and more.